Transformers: Revenge Of The Fallen star Josh Duhamel is set to take on a new romantic comedy alongside Katherine Heigl (Grey's Anatomy). Duhamel has signed on to Warner Brother's Life As We Know It. The story revolves around two unattached adults whose worlds are turned upside down when their mutual best friends die in an accident and name them as caregivers of their orphaned daughter. Heigl and her mother Nancy Heigl are executive producing the film and being directed by Greg Berlanti. Duhamel will next be seen opposite Kristen Bell in Disney's romantic comedy When in Rome, directed by Mark Steven Johnson. Heigl will be seen in Five Killers alongside Ashton Kutcher that's scheduled to be released June 4, 2010.